Friday, 26 September 2025

2nd and 3rd trimester fetal snography

2nd and 3rd trimester fetal snography — Table of Contents (Topic-wise)

Contents (Topic-wise)

Routine examination checklist

Typical items: maternal details, fetal biometry (BPD/HC/AC/FL), fetal lie and presentation, amniotic fluid assessment, placental location, basic fetal anatomy screen (head, face, spine, thorax, abdomen, limbs), Doppler if indicated.

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TIFA examination checklist

Targeted Imaging for Fetal Anomalies (TIFA): extended anatomic survey with dedicated views for heart (4-chamber, outflow tracts), brain (neurosonography), face, kidneys, limbs, and placenta; include measurements, Doppler, and photographic documentation.

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BPP & NST examination checklist

Biophysical profile (BPP): fetal tone, movement, breathing, amniotic fluid volume, and NST. Non-stress test (NST): fetal heart rate acceleration pattern; record baseline, variability, accelerations, decelerations.

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RMT assessment

Risk-modifying tests (RMT) / risk management triage: review maternal risk factors (hypertension, diabetes, infections), prior scans, and decide follow-up frequency; include targeted Doppler, growth charts, and referral to fetal medicine if needed.

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Cervix

Assess cervical length, funneling, and competence on transvaginal or transabdominal scan when indicated; note cerclage or morphological abnormalities.

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Placenta

Document location (anterior/posterior/fundal), grade, thickness, lacunae, signs of abruption, previa, succenturiate lobes, and cord insertion site (marginal, velamentous).

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Umbilical cord

Assess number of vessels (3 vs 2), insertion point, visible knots, coiling, and any cysts or masses; perform cord Doppler (AVA flow) if indicated.

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Amniotic fluid

Measure AFI or deepest vertical pocket, comment on oligohydramnios or polyhydramnios, and correlate with fetal swallowing and renal anatomy.

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Fetal Position and presentation

Document fetal lie (longitudinal/transverse/oblique), presentation (cephalic/breech/shoulder), and engagement; note station if relevant for late pregnancy.

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Sonographic anatomy of fetal head & Spine

Examine skull vault, midline falx, lateral ventricles, cavum septi pellucidi, thalami, cerebellum, cisterna magna, corpus callosum (when feasible), and vertebral alignment in sagittal/coronal planes.

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Measurable component in Fetal head

Common measures: biparietal diameter (BPD), head circumference (HC), occipito-frontal diameter (OFD), transcerebellar diameter (TCD), ventricular atrial width.

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Fetal skull shape

Assess skull contour for dolichocephaly, brachycephaly, plagiocephaly, craniosynostosis signs, and asymmetry; include 3D if needed.

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Cephalic Index (CI)

CI = (BPD / OFD) × 100. Document units and classification (dolichocephalic, mesocephalic, brachycephalic) and comment on clinical relevance.

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Fronto-Occipital Index (FOI)

FOI = (Fronto-occipital diameter / Maximum head breadth) × 100 (or other local definition) — used in some cranial assessments; specify formula used.

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Central Nervous System Anomaly

Screen for major CNS anomalies: anencephaly, holoprosencephaly, ventriculomegaly, Dandy-Walker malformation, agenesis of corpus callosum, etc.; document ventricles, midline, posterior fossa.

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Neural Tube Defects

Include open spina bifida (cranial signs: lemon/banana sign, ventriculomegaly), meningocele, encephalocele; examine spine continuity and overlying soft tissues.

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Sonographic anatomy of fetal face

Assess facial profile, forehead, nose, lips, palate (when possible), eyes, orbits, and maxillary/mandibular morphology in axial and sagittal planes.

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Measurable component in face

Key measures: nasal bone length (NBL), interorbital distance (IOD), binocular distance, mandibular length, inferior facial angle (IFA), fronto-maxillary facial (FMF) angle.

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Facial Ratios and Angles

Document ratios such as NB/mandible, philtrum-to-lip relationships, and angles (FMF, IFA) used for aneuploidy and craniofacial assessment.

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Fetal Facial Anomaly

Note cleft lip/palate, micrognathia, hypertelorism/hypotelorism, nasal bone abnormalities, and syndromic facial patterns; recommend genetic review if indicated.

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Sonographic anatomy of fetal neck

Assess nuchal thickness, cystic hygroma, lymphatic malformations, and neck mass lesions in sagittal and transverse planes.

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Measurable component in fetal neck

Include nuchal translucency (first trimester), nuchal fold (second trimester), neck circumference when required, and measurement of cystic components.

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Fetal neck anomaly

Identify cystic hygroma, teratoma, cervical meningocele, or lymphatic malformations and evaluate for hydrops and chromosomal associations.

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Sonographic anatomy of fetal thorax & heart

Perform standard four-chamber view, outflow tracts, three-vessel view, and axial/longitudinal thoracic assessment; evaluate lungs, pleura, diaphragm.

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Measurable component in fetal thorax & heart

Measurements: cardiac diameter (CD), thoracic diameter (TD), cardiac area (CA), thoracic area (TA), ventricular dimensions, trunk circumference when relevant.

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Cardiac axis

Assess cardiac axis (normal leftward ~45°) in the thorax; deviations may suggest heterotaxy, congenital diaphragmatic hernia, or structural cardiac anomalies.

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Thoracic anomaly

Identify CPAM, diaphragmatic hernia, bronchopulmonary sequestration, pleural effusion, pulmonary hypoplasia, and mediastinal masses; correlate with lung-to-head ratio when applicable.

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Cardiac Anomaly

Document structural anomalies (septal defects, outflow tract abnormalities, valve lesions, complex congenital heart disease) and refer for fetal echocardiography.

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Upper limb sonographic anatomy

Examine clavicles, humerus, radius/ulna, hands, digits, limb movement, and symmetry; measure long bones (humerus) for growth.

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Lower limb sonographic anatomy

Assess femur, tibia/fibula, feet, toes, joint contractures, and limb lengths; note clubfoot, arthrogryposis, or limb reduction defects.

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Musculoskeletal anomaly

Recognize skeletal dysplasias, limb reduction defects, osteogenesis imperfecta signs, and anomalies of the chest wall or spine related to structural disorders.

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Hydrops fetalis diagnosis strategy

Definition: abnormal fluid accumulation in ≥2 fetal compartments (ascites, pleural effusion, pericardial effusion, skin edema). Evaluate for immune vs non-immune causes (alloimmunization, structural anomalies, infections, anemia).

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Associated anomaly

Search for cardiac failure, structural anomalies, chromosomal disorders, infections (parvovirus), tumors (chorioangioma), and twin complications (TTTS). Recommend targeted testing (PUBS, Doppler).

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Trisomy 21 (Down syndrome)

Ultrasound markers: shortened femur, nuchal fold, absent/short nasal bone, cardiac defects (AV septal defect), duodenal atresia, echogenic bowel, increased NT in 1st trimester.

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Trisomy 18 (Edwards syndrome)

Markers: choroid plexus cysts, overlapping fingers, micrognathia, omphalocele, cardiac defects, IUGR, and rocker-bottom feet.

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Trisomy 13 (Patau syndrome)

Markers: holoprosencephaly, cleft lip/palate, polydactyly, cardiac defects, severe CNS anomalies.

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Trisomy 8 mosaicism (Warkany syndrome)

Variable anomalies: skeletal and facial dysmorphism, deep furrowed palms, and other structural anomalies; ultrasound findings may be nonspecific—correlate with genetic testing.

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TORCH infections

Toxoplasma, Others (syphilis, varicella, parvovirus), Rubella, CMV, Herpes—look for growth restriction, ventriculomegaly, calcifications, hepatosplenomegaly, effusions.

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Syphilis (Treponema pallidum)

Findings: hepatosplenomegaly, hydrops, ascites, placental thickening; correlate with serology and maternal history.

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Varicella-zoster virus (VZV)

Possible limb hypoplasia, skin scarring, eye and CNS anomalies if maternal infection early in pregnancy; ultrasound findings are variable.

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Parvovirus B19

Associated with fetal anemia, hydrops fetalis, and high-output cardiac failure—monitor MCA Doppler, consider IUT if severe anemia.

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Human immunodeficiency virus (HIV)

Ultrasound findings nonspecific; correlate with maternal viral status and follow infectious disease guidance for management.

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Hepatitis B virus (HBV)

Ultrasound findings nonspecific; screen mother and manage per obstetric infectious disease protocols.

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Hepatitis C virus (HCV)

Ultrasound findings nonspecific; counsel and follow maternal management guidelines; consider targeted testing when indicated.

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Zika virus

Linked to microcephaly, brain calcifications, ventriculomegaly, cortical malformations—perform neurosonography and serial growth scans.

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Enteroviruses (Coxsackie, Echo)

May cause fetal myocarditis or hydrops; findings variable—correlate with maternal history and fetal status.

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Listeria monocytogenes

May present with fetal growth restriction, preterm labor, and non-specific ultrasound abnormalities; coordinate with maternal testing.

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Malaria (congenital)

Can cause fetal distress and growth restriction; ultrasound findings nonspecific—manage maternal infection promptly.

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Tuberculosis (congenital TB)

Rare; consider when maternal TB is present—findings variable and require multidisciplinary management.

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Fetal Doppler Studies

Include umbilical artery, middle cerebral artery (MCA), ductus venosus, uterine arteries; essential for growth restriction, anemia assessment, and fetal surveillance.

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Fetal Neurosonography

Dedicated brain protocol: coronal and sagittal planes, targeted assessment of ventricles, posterior fossa, cortical development, and midline structures.

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Fetal Echocardiography

Detailed cardiac anatomy and function study: 4-chamber, outflow tracts, three-vessel view, great vessel relationships, valve function, and fetal arrhythmia assessment.

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3D/4D Sonography

Useful for facial anomalies, skeletal dysplasia assessment, spatial relationships, and parental counselling; complements 2D imaging.

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Amniocentesis

Indications: genetic testing, infection studies, lung maturity (selected cases). Technique: ultrasound-guided transabdominal sampling, usually 15–20 weeks. Risks: small risk of miscarriage, leakage, infection.

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Chorionic Villus Sampling (CVS)

Indications: early genetic diagnosis. Technique: transabdominal or transcervical sampling at ~10–13 weeks under ultrasound guidance. Risks: miscarriage, confined placental mosaicism.

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Cordocentesis (Percutaneous Umbilical Blood Sampling, PUBS)

Indications: rapid karyotyping, fetal anemia assessment, infection testing. Technique: ultrasound-guided sampling of umbilical vein near insertion. Risks: fetal bradycardia, bleeding, preterm labor.

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Intrauterine Transfusion (IUT)

Indications: severe fetal anemia (alloimmunization, parvovirus). Technique: transfusion into umbilical vein under ultrasound guidance. Risks: preterm labor, fetal distress, infection.

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Amnioreduction

Indications: symptomatic polyhydramnios or to reduce uterine tension. Technique: ultrasound-guided removal of fluid; repeat as needed. Risks: ROM, infection, preterm labor.

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Amnioinfusion

Indications: oligohydramnios management in selected settings, relieve cord compression in labor. Technique: infusion of warmed saline under guidance; monitor uterine tone and fetal response.

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Fetal Paracentesis / Thoracocentesis

Indications: symptomatic ascites or large pleural effusion causing hydrops or lung compression. Technique: ultrasound-guided drainage; may require repeat drainage or shunt placement.

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Shunt Placements

Indications: obstructive uropathy (vesicoamniotic shunt), fetal hydrothorax (thoracoamniotic shunt). Technique: percutaneous ultrasound-guided placement; monitor for displacement and complications.

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Laser Therapy / Radiofrequency Ablation

Indications: TTTS, TRAP, selective reduction. Technique: fetoscopic laser coagulation of placental anastomoses or percutaneous RFA for specific lesions. Requires specialized centers.

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Fetoscopic Procedures

Indications: laser ablation for TTTS, selected fetal surgeries (spina bifida repair) in specialized centers. Technique: endoscopic instruments with ultrasound and endoscopic guidance; higher resource requirement.

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